I-Heparin sodium CAS 9041-08-1

Incazelo emfushane:

Igama lekhemikhali:I-Heparin lithium

Elinye igama:I-Heparin sodium usawoti

Inombolo ye-CAS:9041-08-1

Ibanga:Umjovo/Isihloko/Oluhlaza

Ukucaciswa:EP/USP/BP/CP/IP

Izakhiwo Zekhemikhali:I-Heparin sodium iyimpushana emhlophe noma emhlophe, ayinaphunga, i-hygroscopic, inyibilika emanzini, ayincibiliki kumakhemikhali aphilayo njenge-ethanol ne-acetone.Ineshaje eqinile engalungile kusisombululo esinamanzi futhi ingahlangana namanye ama-cations akhe ama-molecular complexes.Izixazululo ezinamanzi zizinzile kakhulu ku-pH 7. Inokusetshenziswa okubanzi kwemithi.Isetshenziselwa ukwelapha i-acute myocardial infarction kanye ne-pathogenic hepatitis.Ingasetshenziswa ngokuhambisana ne-ribonucleic acid ukwandisa ukusebenza kahle kwe-hepatitis B. Uma ihlanganiswa ne-chemotherapy, kunenzuzo ukuvimbela i-thrombosis.Inganciphisa i-lipids yegazi futhi ithuthukise ukusebenza komzimba womuntu.futhi unendima.

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Omaka bomkhiqizo

Isicelo

I-Heparin sodium iyisidakamizwa se-anticoagulant, okuyi-mucopolysaccharide substance.Usawoti we-sodium we-glucosamine sulfate okhishwe ku-mucosa yamathumbu ezingulube, izinkomo nezimvu.phakathi.I-Heparin sodium inemisebenzi yokuvimbela ukuhlangana kweplatelet nokubhujiswa, ivimbela ukuguqulwa kwe-fibrinogen ibe yi-fibrin monomer, ivimbele ukwakheka kwe-thromboplastin futhi imelane ne-thromboplastin eyakhiwe, ivimbele ukuguqulwa kwe-prothrombin ibe yi-thrombin ne-antithrombin.

I-Heparin sodium ingabambezela noma ivimbele ukuhlangana kwegazi kokubili ku-vitro kanye ne-vivo.Indlela yayo yokusebenza iyinkimbinkimbi kakhulu futhi ithinta izixhumanisi eziningi enqubweni ye-coagulation.Imisebenzi yayo yilena: ①Ivimbela ukwakheka nokusebenza kwe-thromboplastin, ngaleyo ndlela ivimbele i-prothrombin ekubeni i-thrombin;②Ekugxileni okuphezulu, ingavimbela i-thrombin nezinye izici zokuhlangana, ivimbele i-fibrinogen ekubeni i-fibrin Protein;③ kungavimbela ukuhlanganiswa nokubhujiswa kwama-platelet.Ngaphezu kwalokho, umphumela we-anticoagulant we-sodium heparin usahlobene ne-radical sulfate ekhokhiswa kabi ku-molecule yayo.Izinto ze-alkaline ezishajwe kahle njenge-protamine noma i-toluidine eluhlaza okwesibhakabhaka zinganciphisa ukushajwa kwayo okunegethivu, ngakho-ke ingavimbela i-anticoagulant yayo.i-coagulation.Ngoba i-heparin ingakwazi ukwenza kusebenze futhi ikhulule i-lipoprotein lipase emzimbeni, i-hydrolyze triglyceride kanye ne-low-density lipoprotein kuma-chylomicrons, ngakho futhi inomphumela we-hypolipidemic.

I-Heparin sodium ingasetshenziswa ekwelapheni isifo se-acute thromboembolic, isatshalaliswa nge-intravascular coagulation (DIC).Eminyakeni yamuva nje, i-heparin itholakale inomphumela wokukhipha i-lipids yegazi.Umjovo we-intravenous noma umjovo ojulile we-intramuscular (noma umjovo ongaphansi kwesikhumba), amayunithi angu-5,000 kuya kwangu-10,000 isikhathi ngasinye.I-Heparin sodium ayinabuthi obuncane futhi ukuthambekela ukopha okuzenzakalelayo kuyingozi ebaluleke kakhulu ye-heparin overdose.Ingasebenzi ngomlomo, kufanele ilawulwe ngomjovo.Umjovo we-intramuscular noma umjovo we-subcutaneous uyacasula kakhulu, ngezinye izikhathi ukungezwani komzimba kungase kwenzeke, futhi ukudlula ngokweqile kungase kubangele ukuboshwa kwenhliziyo;ngezinye izikhathi ukulahlekelwa izinwele zesikhashana kanye nesifo sohudo.Ngaphezu kwalokho, kusengadala ukuphuka okuzenzakalelayo.Ukusetshenziswa isikhathi eside kwesinye isikhathi kungabangela i-thrombosis, okungase kube umphumela wokuncipha kwe-anticoagulase-III.I-Heparin sodium i-contraindicated ezigulini ezinokuthambekela ukopha, ukwehluleka okukhulu kwesibindi kanye nezinso, umfutho wegazi ophakeme, i-hemophilia, ukopha kwe-intracranial, isilonda se-peptic, abesifazane abakhulelwe kanye nangemuva kokubeletha, izimila ze-visceral, ukuhlukumezeka nokuhlinzwa.